If all time points after 12 hours are BLQ, omitting them will make no difference. Can we totally delete all the timepoints after 12 hours in Winnonlin and use only the data till 12 hours? Not a big problem for the last sampling points, but don't replace BLQ with missing if you have a measurable concentration at a later time point. In case we enter the values as BLQ in Winnonlin and define Status Code for BLQ as "Missing", does Winnonlin totally omit these time points?īLQ is not missing: you do have a value. » If so, which AUC do we need to report (AUC0-12 or AUC0-72 or both)?ĪUC0-last (from 0 to the last concentration measured for each subject, whatever the time point). AUC calculation will stop at the last measurable concentration for each subject. Including them or not will make no difference. Do we need to include all time points after 12 hours in the "24.0", "36.0", "48.0" and "72.0" format before Winnonlin data analysis? ![]() If we get BLQ values for all time points after 12 hours,
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